{"id":701,"date":"2016-06-22T13:36:31","date_gmt":"2016-06-22T04:36:31","guid":{"rendered":"https:\/\/tokyohart.smg.sg\/?p=701"},"modified":"2017-01-01T04:59:24","modified_gmt":"2016-12-31T19:59:24","slug":"%e8%83%9a%e7%9b%a4%e8%83%9e%e3%81%aepgs%e8%a7%a3%e6%9e%90%e7%b5%90%e6%9e%9c%e3%81%a8%e8%87%aa%e7%84%b6%e6%b5%81%e7%94%a3%e7%b5%a8%e6%af%9b%e3%81%ae%e6%9f%93%e8%89%b2%e4%bd%93%e6%a4%9c%e6%9f%bb","status":"publish","type":"post","link":"https:\/\/tokyohart.smg.sg\/?p=701","title":{"rendered":"\u80da\u76e4\u80de\u306ePGS\u89e3\u6790\u7d50\u679c\u3068\u81ea\u7136\u6d41\u7523\u7d68\u6bdb\u306e\u67d3\u8272\u4f53\u691c\u67fb\u7d50\u679c\u3068\u306e\u6bd4\u8f03"},"content":{"rendered":"<p>PGS\u306e\u7d50\u679c\u3068\u6d41\u7523\u7d68\u6bdb\u691c\u67fb\u306e\u7d50\u679c\u306e\u6bd4\u8f03\u306b\u3088\u308a\u3001\u67d3\u8272\u4f53\u30e2\u30ce\u30bd\u30df\u30fc\u306f\u7740\u5e8a\u3057\u306a\u3044\u3001\u30c8\u30ea\u30bd\u30df\u30fc\u306f\u7740\u5e8a\u3059\u308b\u304c\u6d41\u7523\u306b\u81f3\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>Embryo selection versus natural selection: how do outcomes of comprehensive chromosome screening of blastocysts compare with the analysis of products of conception from early pregnancy loss (dilation and curettage) among an assisted reproductive technology population?<\/p>\n<p>Jorge Rodriguez-Purataa, et al.<br \/>\nFertil Steril. Vol.104, No.6, December 2015 p1460\u20131466.e12<\/p>\n<p>\u300c\u80da\u306e\u9078\u629e\u304b\u81ea\u7136\u306e\u9078\u629e\u304b\uff1a\u4f53\u5916\u53d7\u7cbe\u3092\u884c\u3046\u60a3\u8005\u306b\u5bfe\u3057\u3066\u3001\u80da\u76e4\u80de\u306e\u5305\u62ec\u7684\u67d3\u8272\u4f53\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u7d50\u679c\u3068\u598a\u5a20\u521d\u671f\u6d41\u7523\u3067\u306e\u624b\u8853\u3067\u5f97\u3089\u308c\u305f\u7d44\u7e54\u306e\u89e3\u6790\u7d50\u679c\u306e\u6bd4\u8f03\u300d<\/p>\n<h3>\u8981\u7d04<\/h3>\n<h4>\u76ee\u7684<\/h4>\n<p>\u7740\u5e8a\u524d\u907a\u4f1d\u5b50\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\uff08preimplantation genetic screening: PGS\uff09\u306e\u6570\u7684\u67d3\u8272\u4f53\u7570\u5e38\uff08numerical chromosomal abnormalities: NCAs\uff09\u3068\u81ea\u7136\u6d41\u7523\u624b\u8853\u3067\u5f97\u3089\u308c\u305f\u7d68\u6bdb\u306e\u67d3\u8272\u4f53\u5206\u6790\u306b\u3088\u308b\u6570\u7684\u67d3\u8272\u4f53\u7570\u5e38\u3092\u6bd4\u8f03\u3059\u308b<\/p>\n<h4>\u5834\u6240<\/h4>\n<p>\u5927\u5b66\u75c5\u9662\u306b\u6e96\u305a\u308bIVF\u30bb\u30f3\u30bf\u30fc<\/p>\n<h4>\u65b9\u6cd5<\/h4>\n<p>IVF\u6cbb\u7642\u3092\u53d7\u3051\u3001\u5c11\u306a\u304f\u3068\u3082\u4e00\u3064\u306e\u80da\u751f\u691c\u5f8cPGS\u3092\u53d7\u3051\u305f\u60a3\u8005\u306e\u67d3\u8272\u4f53\u5206\u6790\u5831\u544a\u3068\u3001ART\u5f8c\u598a\u5a20\u3057\u305f\u304c\u7a3d\u7559\u6d41\u7523\u3068\u306a\u308a\u3001\u624b\u8853\u51e6\u7f6e\u3092\u3057\u305f\u60a3\u8005\u306e\u67d3\u8272\u4f53\u5206\u6790\u5831\u544a\u306e\u6570\u7684\u67d3\u8272\u4f53\u7570\u5e38\u983b\u5ea6\u3092\u5f8c\u65b9\u8996\u7684\u306b\u6bd4\u8f03\u3057\u305f\u3002<\/p>\n<h4>\u7d50\u679c<\/h4>\n<p>PGS\u5f8c\u306b1069\uff08trisomy:54.3%, monosomy:45.7%, polyploidy:0%\uff09\u306e\u67d3\u8272\u4f53\u7570\u5e38\u3092\u8a8d\u3081\u3001\u3000trisomy\/ monosomy\u6bd4\u306f0.82\u3067\u3042\u3063\u305f\u3002\u6d41\u7523\u624b\u8853\u5f8c\u306b447\uff08trisomy:83%, monosomy:6.3%, polyploidy:10.7%\uff09\u306e\u67d3\u8272\u4f53\u7570\u5e38\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u9ad8\u983b\u5ea6\u306b\u8a8d\u3081\u3089\u308c\u305f\u67d3\u8272\u4f53\u7570\u5e38\u306f\u4e21\u7fa4\u3067\u540c\u69d8\u3067\u300115\u300116\u300118\u300121\u300122\u756a\u67d3\u8272\u4f53\u306e\u7570\u5e38\u3067\u3042\u3063\u305f\u3002ART\u5f8c\u306e\u6d41\u7523\u691c\u4f53\u306b\u304a\u3044\u3066monosomy\u306f\u307b\u3068\u3093\u3069\u307f\u3089\u308c\u306a\u304b\u3063\u305f(6.3%)\u3002<\/p>\n<h4>\u7d50\u8ad6<\/h4>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001ART\u5f8c\u306e\u4e0d\u598a\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001PGS\u3068\u598a\u5a20\u521d\u671f\u6d41\u7523\u53cc\u65b9\u306b\u304a\u3044\u3066\u6700\u3082\u4e00\u822c\u7684\u306b\u540c\u5b9a\u3055\u308c\u308b\u67d3\u8272\u4f53\u7570\u5e38\u3092\u89e3\u6790\u3057\u305f\u3002PGS\u3067\u306fmonosomy\u306f\u7d0450\uff05\u3092\u5360\u3081\u305f\u304c\u3001\u7740\u5e8a\u5f8c\u3067\u3042\u308b\u6d41\u7523\u624b\u8853\u5f8c\u7d68\u6bdb\u691c\u67fb\u3067\u306f\u307b\u3068\u3093\u3069\u89b3\u5bdf\u3055\u308c\u306a\u304b\u3063\u305f\u3002\u4ee5\u4e0a\u306e\u3053\u3068\u304b\u3089\u3001monosomy\u306fIVF\u60a3\u8005\u306e\u80da\u76e4\u80de\u306b\u304a\u3044\u3066\u3001\u9ad8\u983b\u5ea6\u306b\u8a8d\u3081\u3089\u308c\u308b\u304c\u3001\u4e00\u822c\u7684\u306b\u306f\u7740\u5e8a\u306b\u5bc4\u4e0e\u3057\u306a\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002monosomy\u4ee5\u5916\u306b\u95a2\u3057\u3066\u306f\u3001\u4e21\u7fa4\u9593\u3067\u8a8d\u3081\u3089\u308c\u308b\u67d3\u8272\u4f53\u7570\u5e38\u306f\u5909\u308f\u3089\u306a\u304b\u3063\u305f\u3002<\/p>\n<p>\uff08\u9662\u9577\u306e\u6ce8\u91c8\uff1b\u5e38\u67d3\u8272\u4f53\u306e\u5927\u304d\u306a\u7570\u5e38\u3092\u6301\u3064\u80da\u306f\u80da\u76e4\u80de\u306b\u306a\u308b\u3051\u308c\u3069\u3082\u307b\u3068\u3093\u3069\u7740\u5e8a\u3057\u307e\u305b\u3093\u3002\u751f\u5b58\u3057\u3066\u3044\u304f\u305f\u3081\u306e\u91cd\u8981\u306a\u60c5\u5831\u304c\u6b20\u843d\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u5185\u819c\u304c\u53d7\u3051\u5165\u308c\u306a\u3044\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u306a\u304f\u3066\u3001\u65e9\u304f\u767a\u80b2\u3092\u6b62\u3081\u3066\u3057\u307e\u3046\u306e\u3067\u7740\u5e8a\u3057\u307e\u305b\u3093\u3002\u6027\u67d3\u8272\u4f53\u3067\u3042\u308bY\u67d3\u8272\u4f53\u306f\u6b20\u843d\u3057\u3066\u3044\u3066\u308245XO\u3001\u30bf\u30fc\u30ca\u30fc\u75c7\u5019\u7fa4\u3068\u3057\u3066\u751f\u5b58\u53ef\u80fd\u3067\u3059\u3002\uff09<\/p>\n<p>\u56f31\uff1b\u4e0d\u598a\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u306e\u4f53\u5916\u53d7\u7cbe\u5468\u671f\u306e\u80da\u76e4\u80de\u306e\u7570\u6570\u6027\u67d3\u8272\u4f53\u7570\u5e38\u306e\u51fa\u73fe\u983b\u5ea6\uff08PGS\uff09\u3068\u598a\u5a20\u3057\u3066\u6d41\u7523\u3057\u305f\u6642\u306e\u6d41\u7523\u7269\uff0d\u7d68\u6bdb\u306e\u7570\u6570\u6027\u67d3\u8272\u4f53\u7570\u5e38\u306e\u51fa\u73fe\u983b\u5ea6\uff08D&amp;C\uff09\u3067\u3059\u3002<br \/>\n\u30c8\u30ea\u30bd\u30df\u30fc\u306f\u67d3\u8272\u4f53\u304c1\u672c\u591a\u3044\u3002\u30e2\u30ce\u30bd\u30df\u30fc\u306f1\u672c\u5c11\u306a\u3044\u3002\u30dd\u30ea\u30d7\u30ed\u30a4\u30c7\u30a3\u30fc\u306f\u500d\u6570\u4f53\u3002\u4e21\u8005\u3092\u6bd4\u8f03\u3059\u308b\u3068\u80da\u76e4\u80de\u3067\u306f\u540c\u3058\u983b\u5ea6\u3067\u30c8\u30ea\u30bd\u30df\u30fc\u3068\u30e2\u30ce\u30bd\u30df\u30fc\u304c\u307f\u3089\u308c\u307e\u3059\u3002\u4e00\u65b9\u3001\u6d41\u7523\u7269\u306e\u67d3\u8272\u4f53\u306e\u7570\u6570\u6027\u691c\u67fb\u3067\u306f\u30e2\u30ce\u30bd\u30df\u30fc\u306f\u307b\u3068\u3093\u3069\u898b\u3089\u308c\u307e\u305b\u3093\u3002\u4eca\u56de\u306e\u7814\u7a76\u306ePGS\u306e\u691c\u67fb\u3067\u306f\u67d3\u8272\u4f53\u306e\u500d\u6570\u6027\u306f\u691c\u77e5\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<h3>\u9662\u9577\u306e\u79c1\u898b<\/h3>\n<p>\u672c\u7814\u7a76\u7d50\u679c\u3088\u308a\u3001\u7740\u5e8a\u3057\u3066\u80b2\u3064\u598a\u5a20\u306f\u67d3\u8272\u4f53\u304c\u6b63\u5e38\u304b\u30c8\u30ea\u30bd\u30df\u30fc\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u30a2\u30e1\u30ea\u30ab\u3067\u306ePGS\u306e\u30c7\u30fc\u30bf\u304b\u3089\u60a3\u8005\u3055\u3093\u304c38\u6b73\u304b\u308940\u6b73\u3060\u3068\u6b63\u5e38\u67d3\u8272\u4f53\u80da\u76e4\u80de\u306e\u7387\u306f\u7d0433\uff05\u3067\u3059\u3002\u3059\u306a\u308f\u30613\u500b\u306b1\u500b\u304c\u51fa\u7523\u53ef\u80fd\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u7740\u5e8a\u306b\u554f\u984c\u304c\u306a\u3051\u308c\u30703\u500b\u623b\u305b\u30701\u4eba\u751f\u307e\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u7740\u5e8a\u3084\u51cd\u7d50\u6cd5\u306b\u554f\u984c\u304c\u306a\u3051\u308c\u3070\u30011\u500b\u623b\u3057\u3066\u30013\u4eba\u306b2\u4eba\u306f\u598a\u5a20\u3057(3\u4eba\u306b1\u4eba\u306f\u598a\u5a20\u3057\u306a\u3044)\u30011\u4eba\u306f\u6d41\u7523\u30011\u4eba\u306f\u51fa\u7523\u53ef\u80fd\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14pt;\">&lt;&lt;\u56f31&gt;&gt;<\/span><br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-705 size-full\" src=\"https:\/\/tokyohart.smg.sg\/wp-content\/uploads\/2016\/12\/figure1-2.png\" alt=\"figure1-2\" width=\"512\" height=\"364\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PGS\u306e\u7d50\u679c\u3068\u6d41\u7523\u7d68\u6bdb\u691c\u67fb\u306e\u7d50\u679c\u306e\u6bd4\u8f03\u306b\u3088\u308a\u3001\u67d3\u8272\u4f53\u30e2\u30ce\u30bd\u30df\u30fc\u306f\u7740\u5e8a\u3057\u306a\u3044\u3001\u30c8\u30ea\u30bd\u30df\u30fc\u306f\u7740\u5e8a\u3059\u308b\u304c\u6d41\u7523\u306b\u81f3\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002 Embryo selection versus natural selection: how do outcomes of comprehensive chromosome screening of blastocysts compare with the analysis of products of conception from early pregnancy loss (dilation and curettage) among an assisted reproductive technology population? Jorge Rodriguez-Purataa, et al. Fertil Steril. Vol.104, No.6, December 2015 p1460\u20131466.e12 \u300c\u80da\u306e\u9078\u629e\u304b\u81ea\u7136\u306e\u9078\u629e\u304b\uff1a\u4f53\u5916\u53d7\u7cbe\u3092\u884c\u3046\u60a3\u8005\u306b\u5bfe\u3057\u3066\u3001\u80da\u76e4\u80de\u306e\u5305\u62ec\u7684\u67d3\u8272\u4f53\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u7d50\u679c\u3068\u598a\u5a20\u521d\u671f\u6d41\u7523\u3067\u306e\u624b\u8853\u3067\u5f97\u3089\u308c\u305f\u7d44\u7e54\u306e\u89e3\u6790\u7d50\u679c\u306e\u6bd4\u8f03\u300d \u8981\u7d04 \u76ee\u7684 \u7740\u5e8a\u524d\u907a\u4f1d\u5b50\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\uff08preimplantation genetic screening: PGS\uff09\u306e\u6570\u7684\u67d3\u8272\u4f53\u7570\u5e38\uff08numerical chromosomal abnormalities: NCAs\uff09\u3068\u81ea\u7136\u6d41\u7523\u624b\u8853\u3067\u5f97\u3089\u308c\u305f\u7d68\u6bdb\u306e\u67d3\u8272\u4f53\u5206\u6790\u306b\u3088\u308b\u6570\u7684\u67d3\u8272\u4f53\u7570\u5e38\u3092\u6bd4\u8f03\u3059\u308b \u5834\u6240 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Jorge Rodriguez-Purataa, et al. Fertil Steril. 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Jorge Rodriguez-Purataa, et al. Fertil Steril. 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Jorge Rodriguez-Purataa, et al. Fertil Steril. 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